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Akt Signalling

 

The PKB (RAC/akt) protein kinases are a family of second messenger serine/threonine kinases. Three mammalian isoforms (alpha, beta, gamma) have been identified so far; the alpha-form being the cellular homologue of the v-akt oncogene.
Stimulation of cells with growth factors leads to activation of PKB/akt by a phosphoinositide-3-
kinase dependent signal transduction pathway.

Monoclonal antibodies against:

PKB/Akt, C-Terminus
PKBalpha/Akt1
PKBbeta/Akt2
PKB/Akt, dephospho-Ser 473
PKB/Akt, phospho-Ser 473

Raptor
Rictor

eNOS, phospho-Ser 1177
BAD
GSK3alpha
GSK3alpha, phospho-Ser 21
GSK3beta
GSK3beta, phospho-Ser 9


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