Products:

EGF Receptor/erbB

Binding EGF leads to EGF receptor (EGFR) dimerization and autophosphorylation. In addition, EGFR is phosphorylated by members of the src kinase family at different tyrosine residues, e.g. pTyr 845 in the activation loop.
The receptor acquires its full kinase activity only upon autophosphorylation and phosphorylation at Tyr 845.

Monoclonal antibodies against:

EGFR, phospho-Thr 654
EGFR, phospho-Thr 669
EGFR, phospho-Tyr 845
EGFR, phospho-Tyr 1045
EGFR, phospho-Ser 1047
EGFR, phospho-Tyr 1068
EGFR, phospho-Tyr 1086
EGFR, phospho-Tyr 1148
EGFR, phospho-Tyr 1173
EGFR, dephospho-Tyr 1173
EGFR, aa 960-980
EGFR, aa 1140-1160
EGFR, C-Terminus
EGFR, N-Terminus
EGFR, extracellular domain

erbB2/Her2, phospho-Thr 686
erbB2/Her2, phospho-Tyr 1112
erbB2/Her2, phospho-Ser 1113
erbB2/Her2, phospho-Tyr 1248
erbB2/Her2, aa 1240-1260
erbB2/Her2, intracellular domain

erbB3/Her3, aa 1250-1270
erbB3/Her3, C-Terminus

erbB4/Her4, phospho-Tyr 1242
erbB4/Her4, aa 1230-1250

Also available:

Blocking Peptide phospho-EGFR, pTyr 845
Blocking Peptide phospho-EGFR, pTyr 1045
Blocking Peptide phospho-EGFR, pTyr 1068
Blocking Peptide phospho-EGFR, pTyr 1148
Blocking Peptide phospho-EGFR, pTyr 1173

Blocking Peptide phospho-erbB2, pTyr 877
Blocking Peptide phospho-erbB2, pTyr 1139
Blocking Peptide phospho-erbB2, pTyr 1248
Blocking Peptide phospho-erbB4, pTyr 1188

For further information about the blocking peptides please contact us.

For further product information please click here

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News

New Autophagy-related Monoclonal Antibodies

Monoclonal antibodies Atg5-7C6 and Atg5-11C3 for the detection of endogenous Atg5 in immunoblotting, immunocytochemistry as well as in flow cytometry.

To enlarge picture, please click here.

To enlarge picture, please click here.

For further product information please click here:

0262-100/ATG5-7C6

0263-100/ATG5-11C3

Monoclonal antibody LC3-5H3 for the detection of endogenous LC3A, B, C (microtubule-associated
protein 1 light chain 3 A,B,C) in immunoblotting.

For detailed product information please click here: 0261-100/LC3-5H3

Monoclonal antibody Beclin-12B4 for the detection of endogenous Beclin in immunoblotting.

For further information please click here: 0240-100/Beclin-12B4

New improved Anti-LC3 Monoclonal antibody for Western-Blot Applications

For further information please click here : 0260-100/LC3-2G6

Monoclonal antibody LC3-5F10
for the detection of endogenous
LC3B (microtubule-associated
protein 1 light chain 3B) in immunocytochemistry (see images below) as well as in immunoblotting.

For immunocytochemistry please see also latest citation: J.Biol. Chem., 282 (33),24131-24145, August 17, 2007.

0231-100/LC3-5F10

(A) (B)

Endogenous LC3 punctae detected with anti LC3-MAb
The majority of LC3 was diffusely localized in unstimulated (A) COS7 cells, whereas punctuated signals of LC3 increase after induction of autophagy by vinblastine-stimulation for 2 hours (B). Cells were fixed in paraformaldehyd, followed by methanol. Permeabilization was performed with 0.3% Triton X-100 and endogenous LC3 subsequently detected by MAb 5F10 (Images by courtesy of I. Ciechomska and A. Tolkovsky, University of Cambridge, UK).

For general information please click here.

New PKB/Akt-Signalling-related Monoclonal Antibodies

Monoclonal antibodies Raptor-10E10 and Rictor-1G11 for the detection of endogenous Raptor and Rictor in immunoblotting.

For further information please click here:
0250-100/Rictor-1G11
0255-100/Raptor-10E10