Products:

MAP kinases / SAP kinases

Extracellular signal/mitogen activated protein kinases (MAPK/erk) are a group of proline-directed serine/threonine kinases that are activated by dual phosphorylation of conserved threonine and tyrosine residues within a characteristic Thr-X-Pro peptide motif. The mitogen-activated kinases MAPK1/erk1 and MAPK2/erk2 are both activated by phosphorylation of the Thr-Glu-Tyr motif mediated by MEK1 and MEK2.

Monoclonal antibodies against:

MAP kinase 1/2
MAP kinase 2 (erk2), internal sequence
MAP kinase 2 (erk2), N-Terminus
MAP kinase 2 (erk2), C-Terminus
MAP kinase 7 (erk5), N-Terminus
MEK 1/2
MEK 1, pSer 218/222//MEK2 pSer222/226
MEK 1, N-Terminus
MEK 2, N-Terminus
MKK 3
MKK 7

Stress-activated protein kinases (SAPKs) are strongly activated in response to adverse stimuli such as heat or osmotic shock, UV light and other DNA-damaging reagents, and inhibitors of protein synthesis. They are also activated strongly in response to agonists that are related or produced under conditions of stress, e.g. proinflammatory cytokines.

Monoclonal antibodies against:

SAP kinase 1/2
SAP kinase 1 (jnk)
SAP kinase 1 alpha/jnk2, N-Terminus
SAP kinase 1 beta/jnk3, N-Terminus
SAP kinase 1 gamma/jnk1, N-Terminus
SAP kinase 2 alpha/p38 alpha
SAP kinase 2 delta/p38 delta

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News

New Autophagy-related Monoclonal Antibodies

Monoclonal antibodies Atg5-7C6 and Atg5-11C3 for the detection of endogenous Atg5 in immunoblotting, immunocytochemistry as well as in flow cytometry.

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0262-100/ATG5-7C6

0263-100/ATG5-11C3

Monoclonal antibody LC3-5H3 for the detection of endogenous LC3A, B, C (microtubule-associated
protein 1 light chain 3 A,B,C) in immunoblotting.

For detailed product information please click here: 0261-100/LC3-5H3

Monoclonal antibody Beclin-12B4 for the detection of endogenous Beclin in immunoblotting.

For further information please click here: 0240-100/Beclin-12B4

New improved Anti-LC3 Monoclonal antibody for Western-Blot Applications

For further information please click here : 0260-100/LC3-2G6

Monoclonal antibody LC3-5F10
for the detection of endogenous
LC3B (microtubule-associated
protein 1 light chain 3B) in immunocytochemistry (see images below) as well as in immunoblotting.

For immunocytochemistry please see also latest citation: J.Biol. Chem., 282 (33),24131-24145, August 17, 2007.

0231-100/LC3-5F10

(A) (B)

Endogenous LC3 punctae detected with anti LC3-MAb
The majority of LC3 was diffusely localized in unstimulated (A) COS7 cells, whereas punctuated signals of LC3 increase after induction of autophagy by vinblastine-stimulation for 2 hours (B). Cells were fixed in paraformaldehyd, followed by methanol. Permeabilization was performed with 0.3% Triton X-100 and endogenous LC3 subsequently detected by MAb 5F10 (Images by courtesy of I. Ciechomska and A. Tolkovsky, University of Cambridge, UK).

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New PKB/Akt-Signalling-related Monoclonal Antibodies

Monoclonal antibodies Raptor-10E10 and Rictor-1G11 for the detection of endogenous Raptor and Rictor in immunoblotting.

For further information please click here:
0250-100/Rictor-1G11
0255-100/Raptor-10E10