MAP kinases / SAP kinases


Extracellular signal/mitogen activated protein kinases (MAPK/erk) are a group of proline-directed serine/threonine kinases that are activated by dual phosphorylation of conserved threonine and tyrosine residues within a characteristic Thr-X-Pro peptide motif. The mitogen-activated kinases MAPK1/erk1 and MAPK2/erk2 are both activated by phosphorylation of the Thr-Glu-Tyr motif mediated by MEK1 and MEK2.

Monoclonal antibodies against:

MAP kinase  1/2
MAP kinase 2 (erk2), internal sequence
MAP kinase 2 (erk2), N-Terminus
MAP kinase 2 (erk2), C-Terminus
MAP kinase 7 (erk5), N-Terminus
MEK 1/2
MEK 1, pSer 218/222//MEK2 pSer222/226
MEK 1, N-Terminus
MEK 2, N-Terminus

Stress-activated protein kinases (SAPKs) are strongly activated in response to adverse stimuli such as heat or osmotic shock, UV light and other DNA-damaging reagents, and inhibitors of protein synthesis. They are also activated strongly in response to agonists that are related or produced under conditions of stress, e.g. proinflammatory cytokines.

Monoclonal antibodies against:

SAP kinase 1/2
SAP kinase 1 (jnk)
SAP kinase 1 alpha/jnk2, N-Terminus
SAP kinase 1 beta/jnk3, N-Terminus
SAP kinase 1 gamma/jnk1, N-Terminus
SAP kinase 2 alpha/p38 alpha
SAP kinase 2 delta/p38 delta

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