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Receptor Tyrosine Kinases

 

Receptor tyrosine kinases (RTKs) play a prominent role in the control of cellular processes during embryonic development and in the regulation of many metabolic and physiological processes in a variety of tissues. Consequently, any severe disturbance in the signalling pathway they activate, will result in disease such as cancer, diabetes, immune deficiencies, and cardiovascular diseases.

Monoclonal antibodies against:

Insulin receptor
Insulin receptor, C-Terminus
Insulin receptor, phospho-Tyr 1322
Insulin receptor, phospho-Tyr 1150/1151
Insulin receptor, phospho-Tyr 1322

IGF1 receptor, C-Terminus
IGF1 receptor, phospho-Tyr 1316

c-MET/HGFR

shc
shc, phospho-Tyr 239/240
shc, phospho-Tyr 317
shc/p66, N-Terminus
shc/p66, phospho-Ser 36

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News

pfeil New Autophagy-related Monoclonal    Antibodies
Monoclonal antibodies Atg5-7C6 and Atg5-11C3 for the detection of endogenous Atg5 in immunoblotting, immunocytochemistry as well as in flow cytometry.



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For further product information please click here:

0262-100/ATG5-7C6

0263-100/ATG5-11C3


Monoclonal antibody LC3-5H3 for the detection of endogenous LC3A, B, C (microtubule-associated
protein 1 light chain 3 A,B,C) in immunoblotting.

For detailed product information please click here: 0261-100/LC3-5H3

Monoclonal antibody Beclin-12B4 for the detection of endogenous Beclin in immunoblotting.

For further information please click here: 0240-100/Beclin-12B4

New improved Anti-LC3 Monoclonal antibody for Western-Blot Applications

For further information please click here : 0260-100/LC3-2G6

Monoclonal antibody LC3-5F10
for the detection of endogenous
LC3B (microtubule-associated
protein 1 light chain 3B) in immunocytochemistry (see images below) as well as in immunoblotting.

For immunocytochemistry please see also latest citation: J.Biol. Chem., 282 (33),24131-24145, August 17, 2007.

0231-100/LC3-5F10


(A)                            (B)

Endogenous LC3 punctae detected with anti LC3-MAb
The majority of LC3 was diffusely localized in unstimulated (A) COS7 cells, whereas punctuated signals of LC3 increase after induction of autophagy by vinblastine-stimulation for 2 hours (B). Cells were fixed in paraformaldehyd, followed by methanol. Permeabilization was performed with 0.3% Triton X-100 and endogenous LC3 subsequently detected by MAb 5F10 (Images by courtesy of I. Ciechomska and A. Tolkovsky, University of Cambridge, UK).

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pfeil New PKB/Akt-Signalling-related    Monoclonal Antibodies
Monoclonal antibodies Raptor-10E10 and Rictor-1G11 for the detection of endogenous Raptor and Rictor in immunoblotting.

For further information please click here:
0250-100/Rictor-1G11
0255-100/Raptor-10E10