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Tyrosine kinases

 

Phosphorylation and dephosphorylation of cellular proteins are central steps in transducing extracellular signals to the cell nucleus. Phosphorylated epitopes may serve as docking sites for the assembly of protein complexes or may alter the 3-dimensional protein structure thus modulating enzymatic activity or the ability to undergo protein-protein interactions.
Tyrosine residues are modified by protein tyrosine kinases. Tyrosine phosphorylation may alter the biological activity or mediate the assembly of protein complexes via the interaction of phosphotyrosine residues with SH2 or PID domains.

Monoclonal antibodies against:

FAK, phospho-Tyr 397
fer
Pyk2/CAKb, phospho-Tyr 402
src, N-Terminus
src, phospho-Tyr 416
yes

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pfeil New Autophagy-related Monoclonal    Antibodies
Monoclonal antibodies Atg5-7C6 and Atg5-11C3 for the detection of endogenous Atg5 in immunoblotting, immunocytochemistry as well as in flow cytometry.



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0262-100/ATG5-7C6

0263-100/ATG5-11C3


Monoclonal antibody LC3-5H3 for the detection of endogenous LC3A, B, C (microtubule-associated
protein 1 light chain 3 A,B,C) in immunoblotting.

For detailed product information please click here: 0261-100/LC3-5H3

Monoclonal antibody Beclin-12B4 for the detection of endogenous Beclin in immunoblotting.

For further information please click here: 0240-100/Beclin-12B4

New improved Anti-LC3 Monoclonal antibody for Western-Blot Applications

For further information please click here : 0260-100/LC3-2G6

Monoclonal antibody LC3-5F10
for the detection of endogenous
LC3B (microtubule-associated
protein 1 light chain 3B) in immunocytochemistry (see images below) as well as in immunoblotting.

For immunocytochemistry please see also latest citation: J.Biol. Chem., 282 (33),24131-24145, August 17, 2007.

0231-100/LC3-5F10


(A)                            (B)

Endogenous LC3 punctae detected with anti LC3-MAb
The majority of LC3 was diffusely localized in unstimulated (A) COS7 cells, whereas punctuated signals of LC3 increase after induction of autophagy by vinblastine-stimulation for 2 hours (B). Cells were fixed in paraformaldehyd, followed by methanol. Permeabilization was performed with 0.3% Triton X-100 and endogenous LC3 subsequently detected by MAb 5F10 (Images by courtesy of I. Ciechomska and A. Tolkovsky, University of Cambridge, UK).

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pfeil New PKB/Akt-Signalling-related    Monoclonal Antibodies
Monoclonal antibodies Raptor-10E10 and Rictor-1G11 for the detection of endogenous Raptor and Rictor in immunoblotting.

For further information please click here:
0250-100/Rictor-1G11
0255-100/Raptor-10E10