Tyrosine kinases


Phosphorylation and dephosphorylation of cellular proteins are central steps in transducing extracellular signals to the cell nucleus. Phosphorylated epitopes may serve as docking sites for the assembly of protein complexes or may alter the 3-dimensional protein structure thus modulating enzymatic activity or the ability to undergo protein-protein interactions.
Tyrosine residues are modified by protein tyrosine kinases. Tyrosine phosphorylation may alter the biological activity or mediate the assembly of protein complexes via the interaction of phosphotyrosine residues with SH2 or PID domains.

Monoclonal antibodies against:

FAK, phospho-Tyr 397
Pyk2/CAKb, phospho-Tyr 402
src, N-Terminus
src, phospho-Tyr 416

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